The role of Type I interferons in immunoregulation of breast cancer metastasis to the bone

Abstract

Breast cancer spread to distant sites is often incurable. Our recent findings demonstrate that Type I interferons secreted by tumor cells induce anti-metastatic immune responses that prevent breast cancer metastasis to the bone. This provides novel insights into the importance of the crosstalk between neoplastic and immune cells in the metastatic process. © 2013 Landes Bioscience.